Реакция #42885

Уравнение реакции

4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

sodium hydroxide

HCl

→

4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid

Выход 71.0%

Растворители

—

mixture

THF water

Условия реакции

Обработка

1. 1
   ДругоеThe precipitate was isolated
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried in vacuo

Методика

To a solution of 4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (75 mg) in 2.5 mL of a mixture of THF:water (1.5:1) was added sodium hydroxide (0.442 mL, 1 M, 2.2 eq) and the reaction mixture was stirred for 24 hours at room temperature. Then the reaction mixture was acidified by addition of a solution of aqueous HCl (0.442 mL, 1N, 2.2 eq). The precipitate was isolated, washed with water and dried in vacuo to yield 4-[2-(4-cyclohexyl-phenoxy)-acetylamino]-thiophene-3-carboxylic acid (51 mg, 71%) as a white solid.

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