Реакция #42879

Уравнение реакции

4-[4-(2-Chloro-phenoxy)-butyrylamino]-thiophene-3-carboxylic acid methyl ester

lithium hydroxide monohydrate

→

title compound

Выход 84.1%

4-[4-(2-Chloro-phenoxy)-butyrylamino]-thiophene-3-carboxylic acid

Выход 84.1%

Растворители

tetrahydrofuran

water

Условия реакции

Обработка

1. 1
   ДругоеThe tetrahydofuran was evaporated
2. 2
   workup.ADDITIONthe solution was neutralized by addition of a solution of hydrochloric acid (1N, 0.39 mL)
3. 3
   ФильтрацияThe precipitate was filtered
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried in vacuo

Методика

4-[4-(2-Chloro-phenoxy)-butyrylamino]-thiophene-3-carboxylic acid methyl ester (270 mg, 0.763 mmol) was added to a solution of lithium hydroxide monohydrate (71.1 mg, 1.68 mmol) in a mixture of tetrahydrofuran (7.4 mL) and water (7.4 mL) and the reaction mixture was stirred for 3 hours at room temperature. The tetrahydofuran was evaporated and the solution was neutralized by addition of a solution of hydrochloric acid (1N, 0.39 mL). The precipitate was filtered, washed with water and dried in vacuo to yield the title compound as a yellow solid (218 mg, 84%).

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