Реакция #427806

ord-9fba1917b4d747b5a0294e36635bb50f

Уравнение реакции

CCN(C(=O)C(C)C)c1cc(C(=O)O)cc(-c2ccc(C)cc2)c1
5-(Ethyl-isobutyryl-amino)-4′-methyl-biphenyl-3-carboxylic acid
CC(N)c1cnccn1
1-pyrazin-2-yl-ethylamine
→
CCN(C(=O)C(C)C)c1cc(C(=O)NC(C)c2cnccn2)cc(-c2ccc(C)cc2)c1
5-(ethyl-isobutyryl-amino)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide

Реактанты

CCN(C(=O)C(C)C)c1cc(C(=O)O)cc(-c2ccc(C)cc2)c1
5-(Ethyl-isobutyryl-amino)-4′-methyl-biphenyl-3-carboxylic acid
CC(N)c1cnccn1
1-pyrazin-2-yl-ethylamine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

5-(Ethyl-isobutyryl-amino)-4′-methyl-biphenyl-3-carboxylic acid was reacted with 1-pyrazin-2-yl-ethylamine following the procedure of step 5 of Example 1 to give 5-(ethyl-isobutyryl-amino)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=431.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08895589B2uspto-grants-2014_11