Реакция #42774

Уравнение реакции

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

N-iodosuccinimide

→

3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   Промывкаwashed with water (3×100 ml) and saturated brine (50 ml)
2. 2
   Сушкаdried (MgSO4)
3. 3
   Фильтрацияfiltered
4. 4
   Другоеthe filtrate is evaporated
5. 5
   Другоеto give a pale pink solid

Методика

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

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