Реакция #42606

Уравнение реакции

glutaric anhydride

3-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol

→

5-[((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)amino]-5-oxopentanoic acid

Растворители

chloroform

Условия реакции

Обработка

1. 1
   workup.ADDITIONTo this solution was added
2. 2
   workup.STIRRINGwas stirred overnight at 50° C
3. 3
   КонцентрированиеThe reaction mixture was concentrated in vacuo
4. 4
   Другоеyielding the product

Методика

To a solution of 3-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol (0.500 g, 1.387 mmol) in chloroform (7 ml) was added TEA (0.58 ml, 4.161 mmol) with stirring under nitrogen for 30 min. To this solution was added glutaric anhydride (0.158 g, 1.387 mmol) and reaction was stirred overnight at 50° C. The reaction mixture was concentrated in vacuo, yielding the product. (ES+: 475.2)

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