Реакция #425705

Уравнение реакции

water

3-bromo-2,6-dichloropyridine

sodium methoxide

→

title compound

Выход 93.2%

3-bromo-6-chloro-2-methoxypyridine

Выход 93.2%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеthe organic was evaporated
2. 2
   ФильтрацияThe resulting suspension was filtered
3. 3
   Промывкаthe pad was washed with water for several times
4. 4
   ДругоеThe pad was dried

Методика

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

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