Реакция #4239

Уравнение реакции

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

Выход 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

Выход 92.8%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеthe volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   Температураchilled
4. 4
   Фильтрацияfiltered
5. 5
   Другоеdried

Методика

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

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