Реакция #4222

Уравнение реакции

2-(4-chlorophenyl-ethenyl)-2-tert.-butyl-oxirane

1,2,4-triazole

ethanol

→

1-(4-chlorophenyl)-4,4-dimethyl-3-(imidazol-1-yl-methyl)-1-penten-3-ol

Выход 77.0%

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was then concentrated
2. 2
   ФильтрацияThe solid was then filtered off
3. 3
   Другоеrecrystallised from acetonitrile

Методика

A solution of 17.75 g (0.075 mole) of 2-(4-chlorophenyl-ethenyl)-2-tert.-butyl-oxirane and 6.9 g (0.1 mole) of 1,2,4-triazole in 30 ml of ethanol was heated in a bomb tube at 150° C. for 20 hours. The reaction mixture was then concentrated and the crystalline residue was stirred with ether. The solid was then filtered off and recrystallised from acetonitrile. 17.7 g (77% of theory) of 1-(4-chlorophenyl)-4,4-dimethyl-3-(imidazol-1-yl-methyl)-1-penten-3-ol of melting point 139°-41° C. were obtained.

Источник