Реакция #420393

Уравнение реакции

3-(1-Tert-butoxycarbonyl-piperidin-4-yl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0*1,5*]dec-8-ene-6-carboxylic acid

→

desired product

Выход 92.8%

3-Oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxylic acid

Выход 92.8%

Растворители

hydrochloric acid

Условия реакции

Обработка

1. 1
   Температураthe resulted solution was refluxed for 3 hours
2. 2
   ДругоеThe solvent was removed under reduced pressure
3. 3
   workup.ADDITIONthe residue was diluted with methanol
4. 4
   Другоеdecanted in order

Методика

3-(1-Tert-butoxycarbonyl-piperidin-4-yl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0*1,5*]dec-8-ene-6-carboxylic acid (6.35 g, 16.8 mmol) was dissolved in 37% hydrochloric acid (80 mL) and the resulted solution was refluxed for 3 hours. The solvent was removed under reduced pressure and the residue was diluted with methanol and decanted in order to obtained the desired product as a white solid (4.06 g, 82%).

Источник