Реакция #41991

Уравнение реакции

3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

methyl chloroformate

→

title compound

Выход 36.0%

[3-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-carbamic acid methyl ester

Выход 36.0%

Растворители

ether

pyridine

Условия реакции

Обработка

1. 1
   Промывкаwash with 1N aqueous hydrochloric acid (2×)
2. 2
   Сушкаdry over anhydrous sodium sulfate
3. 3
   Фильтрацияfilter
4. 4
   Концентрированиеconcentrate solution in vacuo
5. 5
   ДругоеPurify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes

Методика

Dissolve 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine (0.35 g, 1.19 mmol) in pyridine (3 ml). Add methyl chloroformate (0.10 ml, 1.31 mmol, 1.1 equivalents) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with 1N aqueous hydrochloric acid (2×), dry over anhydrous sodium sulfate, filter, and concentrate solution in vacuo. Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes to provide the title compound as a white solid (0.15 g, 36%). LC-MS m/z 353.1 (M++1).

Источник