Реакция #418011

Уравнение реакции

water

4-iodo-2-pyridone

1-bromopropane

K2CO3

→

4-Iodo-N-propyl-2-pyridone

Растворители

DMF

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture is extracted with EtOAc
2. 2
   ПромывкаThe organic layer is washed with aq. NaHCO3 solution
3. 3
   Сушкаdried over sodium sulphate
4. 4
   Другоеthe solvent is removed in vacuo
5. 5
   ДругоеThe residue is purified by RP-HPLC (water+0.15% FA, MeOH)

Методика

2.00 g (9.05 mmol) 4-iodo-2-pyridone (XXII.1) are added to 1.00 mL (10.9 mmol) 1-bromopropane and 3.13 g (22.6 mmol) K2CO3 in 10 mL DMF. The mixture is stirred at rt over night. After that time, water is added and the mixture is extracted with EtOAc. The organic layer is washed with aq. NaHCO3 solution, dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC (water+0.15% FA, MeOH).

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