Реакция #418010

Уравнение реакции

acetic anhydride

4-iodo-benzylamine

→

desired product

N-(4-Iodo-benzyl)-acetamide

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   ДругоеAfter that time, the solvent is evaporated
2. 2
   ДругоеThe organic layer is separated
3. 3
   Промывкаwashed with water (1×) and saturated NaHCO3 solution (2×)
4. 4
   СушкаThe organic layer is dried over sodium sulphate
5. 5
   Другоеthe solvent is evaporated

Методика

0.34 mL (3.5 mmol) acetic anhydride are added to 750 mg (3.22 mmol) 4-iodo-benzylamine in 15 ml acetic acid and the mixture is stirred at rt for 4 h. After that time, the solvent is evaporated and the residue partitionated between TBME and water. The organic layer is separated, washed with water (1×) and saturated NaHCO3 solution (2×). The organic layer is dried over sodium sulphate and the solvent is evaporated to yield the desired product.

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