Реакция #418009

Уравнение реакции

ethylamine

3-(4-iodo-phenyl)-2-methyl-propionic acid

TBTU

DIPEA

→

desired product

N-Ethyl-3-(4-iodo-phenyl)-2-methyl-propionamide

Растворители

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture is stirred for 12 h at rt
2. 2
   ДругоеAfter that time, the solvent is evaporated
3. 3
   Другоеthe residue is purified by HPLC (Waters Xbridge 5 μm; eluent A: water+0.3% NH4OH, eluent B: MeOH)

Методика

To 0.17 mg (0.59 mmol) 3-(4-iodo-phenyl)-2-methyl-propionic acid (XI.5) in 1 mL DMF, 0.28 mg (0.88 mmol) TBTU and 0.50 mL (2.9 mmol) DIPEA are added. The mixture is stirred for 15 min at rt. After that time, 106 mg (2.34 mmol) ethylamine are added and the mixture is stirred for 12 h at rt. After that time, the solvent is evaporated and the residue is purified by HPLC (Waters Xbridge 5 μm; eluent A: water+0.3% NH4OH, eluent B: MeOH) to yield the desired product.

Источник