Реакция #418005

Уравнение реакции

potassium hydrogensulfate

lithiumhydroxide

hydrogen peroxide

2-methyl-2-[4-(4-propoxy-phenylethynyl)-phenyl]-propionic acid methyl ester

→

desired product

2-Methyl-2-[4-(4-propoxy-phenylethynyl)-phenyl]-propionic acid

Растворители

water

THF

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitate is filtered off
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried at 45° C.

Методика

A mixture of 26 mg (1.1 mmol) lithiumhydroxide and 99 μL (1.1 mmol) hydrogen peroxide in 0.7 mL water is added to 0.25 g (0.74 mmol) 2-methyl-2-[4-(4-propoxy-phenylethynyl)-phenyl]-propionic acid methyl ester (XI.4) in 7 mL THF. The reaction mixture is stirred at rt for 5 d. After that time, 0.5 N potassium hydrogensulfate solution is added. The precipitate is filtered off, washed with water and dried at 45° C. to yield the desired product.

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