Реакция #418004

Уравнение реакции

HCl

3-[4-(4-ethoxy-phenylethynyl)-phenyl]-propionic acid ethyl ester

NaOH

→

desired product

3-[4-(4-Ethoxy-phenylethynyl)-phenyl]-propionic acid

Растворители

water

MeOH

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitate is filtered off
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried at 45° C.

Методика

To 750 mg (2.33 mmol) 3-[4-(4-ethoxy-phenylethynyl)-phenyl]-propionic acid ethyl ester (XIII.1) in 15 mL MeOH are added 3.49 mL (6.98 mmol) 2N NaOH solution and the mixture is stirred at rt for 12 h. After that time, 7.0 mL 2N HCl are added and the mixture is diluted with water. The precipitate is filtered off, washed with water and dried at 45° C. to yield the desired product.

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