Реакция #418001

Уравнение реакции

2-(4-bromo-phenyl)-2-methyl-propionic acid methyl ester

sodium iodide

N,N′-dimethylethylendiamine

→

desired product

2-(4-Iodo-phenyl)-2-methyl-propionic acid methyl ester

Растворители

1,4-dioxane

EtOAc

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Промывкаwashed with 5% ammonia and water
3. 3
   СушкаThe organic layer is dried over sodium sulphate
4. 4
   ДругоеThe solvent is evaporated

Методика

To 0.45 g (1.7 mmol) 2-(4-bromo-phenyl)-2-methyl-propionic acid methyl ester (WO2008/002671) in 1.5 mL 1,4-dioxane are added 34 mg (0.18 mmol) copper(I) iodide, 0.53 g (3.5 mmol) sodium iodide and 0.04 mL (0.35 mmol) N,N′-dimethylethylendiamine under inert gas atmosphere. The mixture is stirred at 110° C. for 12 h. After cooling, the mixture is diluted with EtOAc and washed with 5% ammonia and water. The organic layer is dried over sodium sulphate. The solvent is evaporated to yield the desired product.

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