Реакция #418000

Уравнение реакции

2-bromo-1-(4-iodo-phenyl)-ethanone

4-methylimidazole

→

desired product

1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

Растворители

ACN

Условия реакции

Обработка

1. 1
   ДругоеAfter that time, the solvent is evaporated
2. 2
   ПромывкаThe mixture is washed with water and brine (2×)
3. 3
   Сушкаthe organic layer is dried over magnesium sulphate
4. 4
   ДругоеThe solvent is evaporated
5. 5
   Другоеthe residue is recrystallized from diethyl ether

Методика

To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.

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