Реакция #417999

Уравнение реакции

water

4-iodo-benzaldehyde

2-amino-pyridine

sodium triacetoxyborohydride

→

desired product

(4-Iodo-benzyl)-pyridin-2-yl-amine

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture is stirred for 1 h at 50° C
2. 2
   Экстракцияthe mixture is extracted with EtOAc
3. 3
   СушкаThe organic layer is dried over magnesium sulphate
4. 4
   Другоеthe solvent is removed in vacuo
5. 5
   ДругоеThe residue is purified by RP-HPLC

Методика

2.00 g (8.62 mmol) 4-iodo-benzaldehyde are added to 0.811 g (8.62 mmol) 2-amino-pyridine in 20 mL THF and the mixture is stirred for 1 h at 50° C. After that time, 4.57 g (21.5 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 1 h at 50° C. Subsequently, water is added and the mixture is extracted with EtOAc. The organic layer is dried over magnesium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC to yield the desired product.

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