Реакция #417998

Уравнение реакции

sodium

n-propanol

2-chloro-4-iodo-pyridine

→

4-Iodo-2-propoxy-pyridine

Растворители

water

Условия реакции

Обработка

1. 1
   workup.STIRRINGThe mixture is stirred
2. 2
   Температураat reflux for 3 h
3. 3
   Другоеthe solvent is removed in vacuo
4. 4
   Фильтрацияfiltrated
5. 5
   Другоеthe filtrate is purified by RP-HPLC (MeOH/H2O/NH3)

Методика

0.58 g (25 mmol) sodium are carefully added to 40 mL n-propanol in several portions. The mixture is stirred for 45 min. After that time, 6.0 g (25 mmol) 2-chloro-4-iodo-pyridine are slowly added to the mixture. The mixture is stirred at reflux for 3 h. Subsequently, water is added and the solvent is removed in vacuo. The residue is taken up in 20 mL DMF/MeOH, filtrated and the filtrate is purified by RP-HPLC (MeOH/H2O/NH3).

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