Реакция #417997

Уравнение реакции

2-(4-iodo-benzyl)-2-methyl-malonic acid diethyl ester

NaOH

→

desired product

3-(4-Iodo-phenyl)-2-methyl-propionic acid

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Температураat reflux for 2 h
2. 2
   ДругоеThe solvent is evaporated
3. 3
   workup.ADDITION35 mL 4N HCl are added
4. 4
   workup.STIRRINGThe mixture is stirred at 60° C. for 12 h
5. 5
   ФильтрацияThe solid is filtered off

Методика

To 2.30 g (5.89 mmol) 2-(4-iodo-benzyl)-2-methyl-malonic acid diethyl ester (V.1) in 30 mL EtOH are added 30 mL 1N NaOH. The mixture is stirred at reflux for 2 h. The solvent is evaporated and 35 mL 4N HCl are added. The mixture is stirred at 60° C. for 12 h. The solid is filtered off to yield the desired product.

Источник