Реакция #417996

Уравнение реакции

sodium

2-methyl-malonic acid diethyl ester

4-iodobenzyl bromide

→

desired product

2-(4-Iodo-benzyl)-2-methyl-malonic acid diethyl ester

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Температураat reflux for 15 min
2. 2
   workup.STIRRINGThe mixture is stirred
3. 3
   Температураat reflux for 12 h
4. 4
   ДругоеAfter that time, the solvent is evaporated
5. 5
   Другоеthe residue is purified by column chromatography (silicia gel; cyclohexane:EtOAc 98:2)

Методика

220 mg (10 mmol) sodium in small pieces are added to 15 mL EtOH. After 15 min 1.65 mL (9.70 mmol) 2-methyl-malonic acid diethyl ester are added. The mixture is stirred at reflux for 15 min and subsequently 3.00 g (10.1 mmol) 4-iodobenzyl bromide are added. The mixture is stirred at reflux for 12 h. After that time, the solvent is evaporated and the residue is purified by column chromatography (silicia gel; cyclohexane:EtOAc 98:2) to yield the desired product.

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