Реакция #417995

Уравнение реакции

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride

2-(4-Iodo-phenyl)-propionic acid

DIPEA

ethylamine hydrochlorid

→

N-Ethyl-2-(4-iodo-phenyl)-propionamide

Растворители

DCM

Условия реакции

Обработка

1. 1
   ТемператураSubsequently, cooling
2. 2
   Другоеis removed
3. 3
   ПромывкаAfter that time, the mixture is washed with water and brine
4. 4
   Сушкаdried over sodium sulphate
5. 5
   Другоеthe solvent is evaporated
6. 6
   ДругоеThe residue is purified by column chromatography (silicia gel; heptane:EtOAc 50:50)

Методика

1.97 g (7.14 mmol) 2-(4-Iodo-phenyl)-propionic acid (111.1) and 1.25 mL (7.14 mmol) DIPEA are added to 582 mg (7.14 mmol) ethylamine hydrochlorid in 70 mL DCM. 1.64 g (8.57 mmol) N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 194 mg (1.43 mmol) 1-hydroxy-7-azabenotriazole are added at 0° C. Subsequently, cooling is removed and the mixture is stirred for 20 h at rt. After that time, the mixture is washed with water and brine, dried over sodium sulphate and the solvent is evaporated. The residue is purified by column chromatography (silicia gel; heptane:EtOAc 50:50).

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