Реакция #417994

Уравнение реакции

lithiumhydroxide monohydrate

2-(4-iodo-phenyl)-propionic acid methyl ester

→

2-(4-Iodo-phenyl)-propionic acid

Растворители

water

THF

MeOH

Условия реакции

Обработка

1. 1
   ТемператураCooling
2. 2
   Другоеis removed
3. 3
   Экстракцияextracted with DCM
4. 4
   ПромывкаThe organic layer is washed with brine
5. 5
   Сушкаdried over sodium sulphate
6. 6
   Другоеthe solvent is evaporated

Методика

0.610 g (14.6 mmol) lithiumhydroxide monohydrate in 15 mL water are added to 2.12 g (7.31 mmol) 2-(4-iodo-phenyl)-propionic acid methyl ester (Bioorg. Med. Chem. Lett. 2010, 20, 896) in 20 mL THF and 12 mL MeOH at 0° C. Cooling is removed and the mixture is stirred at rt for 2 h. After that time, the mixture is acidified with 1 N HCl to pH˜1 and extracted with DCM. The organic layer is washed with brine, dried over sodium sulphate and the solvent is evaporated. The product is used without further purification in Example IV.1

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