Реакция #417991

Уравнение реакции

dichloromethane

3-(3-aminobenzyl)-5-chloro-3H-benzothiazol-2-one

3-(4-methylpiperazin-1-yl)propane 1-chloroformate

DIPEA

→

3-(4-methylpiperazin-1-yl)propyl [3-(5-chloro-2-oxobenzothiazol-3-ylmethyl)phenyl]carbamate

Растворители

THF

Условия реакции

Обработка

1. 1
   Промывкаis subsequently washed with 10 ml of 2N NaOH
2. 2
   Другоеdried
3. 3
   Другоеevaporated
4. 4
   ДругоеThe crude product is purified by means of preparative HPLC

Методика

173 mg (0.36 mmol) of 3-(3-aminobenzyl)-5-chloro-3H-benzothiazol-2-one and 198 mg (0.67 mmol) of 3-(4-methylpiperazin-1-yl)propane 1-chloroformate are suspended in 3 ml of THF, and 253 μl (1.46 mmol) of DIPEA are added. The reaction mixture is stirred overnight at room temperature. 50 ml of dichloromethane are added to the suspension, which is subsequently washed with 10 ml of 2N NaOH, dried and evaporated. The crude product is purified by means of preparative HPLC. The product “A13” is in the form of the trifluoroacetate.

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