Реакция #417988

Уравнение реакции

2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl

methylpiperazine

potassium phosphate trihydrate

2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl

3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

→

3-{3-[5-(4-methylpiperazin-1-yl)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

Растворители

toluene

Water

Условия реакции

Обработка

1. 1
   Температураcooled to room temperature
2. 2
   workup.STIRRINGstirred at 100° C. for a further 24 h under an argon atmosphere
3. 3
   Экстракцияis then extracted with ethyl acetate
4. 4
   Другоеdried
5. 5
   ДругоеThe crude product is purified by means of preparative HPLC

Методика

513 mg (1 mmol) of 3-[3-(5-iodopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one is suspended in toluene, briefly heated to 100° C. and cooled to room temperature. 134 μl (1.2 mmol) of methylpiperazine, 297 mg (1.4 mmol) of potassium phosphate trihydrate, and 33 mg (0.08 mmol) of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl and 18 mg (0.02 mmol) of tris(benzylideneacetone)dipalladium are subsequently added and stirred at 100° C. under an argon atmosphere. 33 mg (0.08 mmol) of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl and 18 mg (0.02 mmol) of tris(benzylideneacetone)dipalladium are subsequently again added and stirred at 100° C. for a further 24 h under an argon atmosphere. Water is added to the reaction mixture, which is then extracted with ethyl acetate and dried. The crude product is purified by means of preparative HPLC. The product is in the form of the trifluoroacetate.

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