Реакция #417978

Уравнение реакции

sulfuric acid

methyl 3-[5-(dimethylaminomethyleneamino)pyrimidin-2-yl]benzoate

→

3-(5-hydroxypyrimidin-2-yl)benzoic acid

Растворители

water

water

Условия реакции

Обработка

1. 1
   Температураthe mixture is heated at the boil for 4 hours
2. 2
   Фильтрацияfiltered off with suction
3. 3
   ПромывкаThe residue is washed with water
4. 4
   Другоеdried in vacuo
5. 5
   Другое=2.19 min (method A)

Методика

160 ml (2.88 mol) of concentrated sulfuric acid are added to a suspension of 103.5 g (364 mmol) of methyl 3-[5-(dimethylaminomethyleneamino)pyrimidin-2-yl]benzoate in 1.3 l of water, and the mixture is heated at the boil for 4 hours. The reaction mixture is cooled to room temperature, diluted with water and filtered off with suction. The residue is washed with water and dried in vacuo: 3-(5-hydroxypyrimidin-2-yl)benzoic acid as brownish crystals; m.p. 293-295°; ESI 217 (M+H); HPLC: Rt.=2.19 min (method A).

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