Реакция #417976

Уравнение реакции

sulfuric acid

3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid

methanol

water

→

methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate

Условия реакции

Обработка

1. 1
   Температураthe mixture is heated at the boil for 18 hours
2. 2
   ТемператураThe reaction mixture is cooled in an ice bath
3. 3
   Фильтрацияthe mixture is filtered off with suction
4. 4
   Промывкаwashed well with water
5. 5
   Другое=2.65 min (method A)

Методика

7.83 ml (147 mmol) of concentrated sulfuric acid are added to a suspension of 30.0 g (147 mmol) of 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid in 150 ml of methanol, and the mixture is heated at the boil for 18 hours. The reaction mixture is cooled in an ice bath, water is added, the mixture is filtered off with suction and washed well with water: methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate as colourless crystals; m.p. 81° C., ESI 219 (M+H), HPLC: Rt.=2.65 min (method A).

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