Реакция #417970

Уравнение реакции

Acetic acid

25b

1-bromo-4-nitro-2-(2-phenoxy-ethoxy)-benzene

→

aniline

Выход 84.0%

4-bromo-3-(2-phenoxy-ethoxy)-phenylamine

Выход 84.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   Другоеthe crude was purified by flash column chromatography

Методика

Acetic acid (1.068 mL, 18 mmol) was added to the mixture of 25b (600 mg, 1.8 mmol) and zinc dust (1.157 g, 18.0 mmol) in ethanol (10 mL) at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hrs. The mixture was filtered, the solvent distilled off under reduced pressure and the crude was purified by flash column chromatography to obtain the aniline 25c in 84% yield.

Источник