Реакция #417964

Уравнение реакции

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

Выход 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

Выход 93.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураthe reaction was refluxed for 5 mins
2. 2
   ФильтрацияIt was filtered off
3. 3
   Промывкаwashed with water (10 mL)
4. 4
   Другоеdried

Методика

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

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