Реакция #417951

Уравнение реакции

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

Растворители

DCM

Условия реакции

Обработка

1. 1
   ДругоеThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   Фильтрацияthe resulting mixture is filtered
4. 4
   Сушкаdried over MgSO4
5. 5
   Фильтрацияfiltered again
6. 6
   Другоеthe solvent is removed in vacuo

Методика

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

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