Реакция #417949

Уравнение реакции

5-bromo-2-fluoropyridine

cyclopropane methanol

NaH

→

5-Bromo-2-cyclopropylmethoxy-pyridine

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture is stirred at r.t. over night
2. 2
   ДругоеThe reaction is quenched by the addition of water
3. 3
   Экстракцияextracted with EtOAc
4. 4
   Сушкаdried over MgSO4
5. 5
   Фильтрацияfiltered
6. 6
   Другоеthe solvent is removed in vacuo
7. 7
   ДругоеThe crude product is purified by HPLC (MeOH/H2O/FA)

Методика

0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA).

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