Реакция #417948

Уравнение реакции

2-bromo-5-hydroxypyridine

1-bromopropane

K2CO3

→

2-Bromo-5-propoxy-pyridine

Растворители

ACN

Условия реакции

Обработка

1. 1
   Температураat reflux over night
2. 2
   ДругоеAfterwards the reaction is quenched by the addition of water
3. 3
   Экстракцияextracted with TBME
4. 4
   Сушкаdried over MgSO4
5. 5
   Фильтрацияfiltered
6. 6
   Другоеthe solvent is removed in vacuo
7. 7
   ДругоеThe crude product is purified by column chromatography (silica gel, PE/EtOAc)

Методика

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

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