Реакция #417946

Уравнение реакции

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

Условия реакции

Обработка

1. 1
   ДругоеThe reaction is quenched by the addition of water
2. 2
   Экстракцияextracted with DCM
3. 3
   Сушкаlayers are dried over MgSO4
4. 4
   Фильтрацияfiltered

Методика

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

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