Реакция #41733

Уравнение реакции

2-chloro-5-methoxybenzoxazole

4-bromoaniline

diisopropylethylamine

→

(4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   КонцентрированиеThe resultant mixture was concentrated
2. 2
   Другоеpartitioned between ethyl acetate and water
3. 3
   ПромывкаThe organic layer was washed with brine
4. 4
   Другоеdried
5. 5
   ДругоеPurification on silica gel

Методика

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

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