Реакция #41532

Уравнение реакции

[1,2,4]triazole

sodium hydride

dimethylformamide

4-(4-fluoro-phenoxy)-2-methanesulfonyl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-2-[1,2,4]triazol-1-yl-1H-benzimidazole

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеthe reaction liquid
2. 2
   ДругоеThe reaction liquid
3. 3
   Промывкаwashed with water and saturated saline in order
4. 4
   Сушкаdried with anhydrous magnesium sulfate
5. 5
   ДругоеThe solvent was evaporated away under reduced pressure
6. 6
   Другоеthe resulting residue was purified
7. 7
   Другоеthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), ethyl acetate)
8. 8
   Другоеto obtain the entitled compound

Методика

5.0 mg of sodium hydride was added to a dimethylformamide (0.5 ml) solution of 16 mg of 4-(4-fluoro-phenoxy)-2-methanesulfonyl-6-(pyridin-3-yloxy)-1H-benzimidazole, and then 10.4 mg of [1,2,4]triazole was added to it, and the reaction liquid was stirred overnight at 160° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), ethyl acetate) to obtain the entitled compound.

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