Реакция #41528

Уравнение реакции

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеthe reaction liquid
2. 2
   ДругоеThe reaction liquid
3. 3
   Промывкаwashed with water and saturated saline in order
4. 4
   Сушкаdried with anhydrous magnesium sulfate
5. 5
   ДругоеThe solvent was evaporated away under reduced pressure
6. 6
   Другоеto obtain the entitled compound

Методика

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

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