Реакция #41460

Уравнение реакции

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

Выход 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Выход 98.0%

Растворители

Water

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe beige-orange precipitate that formed
2. 2
   Другоеwas collected by,
3. 3
   Фильтрацияfiltration
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried in vacuo

Методика

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

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