Реакция #41456

Уравнение реакции

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Выход 98.1%

Растворители

Water

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe light yellow precipitate that formed
2. 2
   Фильтрацияwas collected by filtration
3. 3
   Промывкаwashed with water
4. 4
   Другоеdried in vacuo

Методика

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

Источник