Реакция #41344

Уравнение реакции

5-Iodo-6-methylindazole

p-fluorobenzeneboronic acid

pyridine

p-fluorobenzeneboronic acid

pyridine

→

subtitle compound

Выход 51.1%

1-(4-Fluorophenyl)-5-iodo-6-methylindazole

Выход 51.1%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered through celite
2. 2
   КонцентрированиеThe filtrate was concentrated
3. 3
   Другоеpurified by column chromatography (SiO2, toluene)

Методика

5-Iodo-6-methylindazole (1.3 g, 5.0 mmol), p-fluorobenzeneboronic acid (1.4 g, 10 mmol), anhydrous copper(II) acetate (1.4 g, 7.5 mmol) and pyridine (0.80 mL, 10 mmol) were stirred in dichloromethane (30 mL) overnight. Additional portions of p-fluorobenzeneboronic acid (0.47 g, 3.4 mmol), anhydrous copper(II) acetate (0.45 g, 2.5 mmol) and pyridine (0.27 mL, 3.4 mmol) were added. The mixture was filtered through celite after stirring for an additional night. The filtrate was concentrated and purified by column chromatography (SiO2, toluene) to give the subtitle compound (0.90 g, 51%) as a light orange powder.

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