Реакция #41327

ord-07a7eb7b05044e3283da4d58a3c39cb0

Уравнение реакции

C[C@@H](N)[C@@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1
(1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine
O=C(Cl)C(F)F
difluoroacetyl chloride
→
C[C@H](NC(=O)CF)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1
2-Fluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide

Реактанты

C[C@@H](N)[C@@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1
(1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine
O=C(Cl)C(F)F
difluoroacetyl chloride

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеPrepared

Методика

Prepared as described in Example 1 using (1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine (1a, 36 mg, 100 μmol) and difluoroacetyl chloride (29 mg, 300 μmol). Yield 40 mg (95%).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07728030B2uspto-grants-2010_06