Реакция #40922

Уравнение реакции

diethyl ether

ketal

[1-(1,4-dioxa-spiro[4.5]dec-8-yl)-3-phenylpropyl]-dimethylamine

NaOH

hydrochloric acid

→

ketone

4-(1-dimethylamino-3-phenylpropyl)-cyclohexanone

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwhile cooling with ice
2. 2
   Экстракцияwas extracted with dichloromethane (3×100 ml)
3. 3
   Другоеdried
4. 4
   Концентрированиеconcentrated by evaporation

Методика

The crude product of the ketal 7e (29.6 g, 97 mmole) was dissolved in water (44 ml), concentrated hydrochloric acid (64 ml) was added, and the mixture was stirred for 20 hours at RT. The reaction mixture was shaken with diethyl ether (2×100 ml), the aqueous phase was made alkaline with 5N NaOH while cooling with ice, and was extracted with dichloromethane (3×100 ml), dried, and concentrated by evaporation. The ketone was isolated as a colorless oil.

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