Реакция #40917

Уравнение реакции

diethyl ether

4-oxo-cyclohexanecarboxylic acid ethyl ester

ethylene glycol

p-toluenesulfonic acid

→

1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

Растворители

toluene

Условия реакции

Обработка

1. 1
   Промывкаwashed with water, sodium hydrogen carbonate solution and sodium chloride solution
2. 2
   СушкаThe solution was dried (Na2SO4)
3. 3
   Концентрированиеconcentrated by evaporation in vacuo
4. 4
   Другоеthe remaining colorless liquid was processed further without purification

Методика

4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.

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