Реакция #4080

Уравнение реакции

sodium borohydride

calcium chloride

cholesta-1,4,6-trien-3-one

isopropenyl acetate

→

cholesta-1,5,7-trien-3-ol

Выход 63.0%

Растворители

acetic acid

ethanol

methanol

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Температураunder reflux for 3 hours
3. 3
   ПромывкаThe reaction solution was thoroughly washed with water until it
4. 4
   Сушкаdried over sodium sulfate A solution of the
5. 5
   Другоеthus obtained
6. 6
   Концентрированиеconcentrate in 600 ml of ether
7. 7
   workup.ADDITIONwas added dropwise at a temperature of -5° C. to -10° C. to a reducer solution
8. 8
   Другоеbeing prepared
9. 9
   workup.ADDITIONadding dropwise
10. 10
    workup.ADDITIONwas added to the reaction mixture
11. 11
    Экстракцияthe resultant solution was extracted with ether
12. 12
    ДругоеThe ethereal layer separated
13. 13
    Промывкаwas washed with water
14. 14
    Сушкаsodium bicarbonate solution, dried over sodium sulfate
15. 15
    workup.DISTILLATIONdistilled under reduced pressure
16. 16
    Другоеto remove ether
17. 17
    ДругоеThe residue was recrystallized from acetone

Методика

To a mixture of 38 g (0.1 mol) of cholesta-1,4,6-trien-3-one and 17 g (0.1 mol) of paratoluenesulfonic acid were added 400 g (4 mol) of isopropenyl acetate, and the mixture was heated under reflux for 3 hours. The reaction solution was thoroughly washed with water until it was neutral, and dried over sodium sulfate A solution of the thus obtained concentrate in 600 ml of ether was added dropwise at a temperature of -5° C. to -10° C. to a reducer solution and stirred at 0° C. for 6 hours, said reducer solution being prepared by cooling a solution of 90 g of calcium chloride in 1,500 ml of methanol to a temperature of -5° C. to -10° C., then adding dropwise thereto a solution of 45 g of sodium borohydride in 2,000 ml of ethanol, and stirring the reaction solution at a temperature of -5° C. to -10° C. for 60 minutes. After completion of the reaction, 50% acetic acid was added to the reaction mixture and the resultant solution was extracted with ether. The ethereal layer separated was washed with water and then sodium bicarbonate solution, dried over sodium sulfate and distilled under reduced pressure to remove ether therefrom. The residue was recrystallized from acetone to yield 23.9 g of cholesta-1,5,7-trien-3-ol (IV), m.p. 126°-127° C. The yield was 63%.

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