Реакция #40364

Уравнение реакции

4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline

acetonitrile

N-(dimethoxymethyl)-N-methylethanamine

→

N′-{4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimido-formamide

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ТемператураThe reaction mixture was refluxed for 20 hrs
3. 3
   КонцентрированиеThe reaction mixture was concentrated in vacuo
4. 4
   workup.ADDITIONdiluted with ethyl acetate
5. 5
   Промывкаwashed with water
6. 6
   СушкаThe organic layer was dried over magnesium sulfate
7. 7
   Концентрированиеconcentrated in vacuo
8. 8
   Другоеyielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45

Методика

To a mixture of 310 mg (0.8 mmol) of 4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline in 20 ml acetonitrile 208 mg (1.5 mmol) of N-(dimethoxymethyl)-N-methylethanamine (77% pure) was added. The reaction mixture was refluxed for 20 hrs. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate and concentrated in vacuo yielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45.

Источник