Реакция #4027

Уравнение реакции

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураthe solution was heated for 15 hours
2. 2
   Температураunder reflux
3. 3
   Экстракцияthe organic layer was extracted with chloroform
4. 4
   ПромывкаAfter washing the
5. 5
   Экстракцияextract three times with water
6. 6
   Другоеthe chloroform was removed by distillation
7. 7
   ДругоеThe residue was recrystallized from a mixture of acetone and hexane

Методика

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

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