Реакция #3968

Уравнение реакции

2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine

hydrazine hydrate

→

2-(2-Methoxy-4-amino-5-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

Растворители

isopropanol

Условия реакции

Обработка

1. 1
   Температураrefluxed for 1.75 hours
2. 2
   КонцентрированиеThe reaction mixture is concentrated by evaporation
3. 3
   Другоеthe residue is triturated with 50 ml of ice water
4. 4
   Другоеthe product precipitated
5. 5
   Другоеis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)]

Методика

One half gram of 2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine is suspended in 10 ml of isopropanol, mixed with 0.5 ml of 80% hydrazine hydrate, and refluxed for 1.75 hours with stirring. The reaction mixture is concentrated by evaporation, the residue is triturated with 50 ml of ice water, and the product precipitated is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)].

Источник