Реакция #3966

Уравнение реакции

potassium hydroxide

8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine

→

8-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxy-purine

Растворители

benzyl alcohol

Условия реакции

Обработка

1. 1
   Температураcooled
2. 2
   Фильтрацияfiltered
3. 3
   workup.ADDITIONthe filtrate is mixed with ether
4. 4
   Другоеthe precipitate obtained
5. 5
   Другоеis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)]

Методика

An amount of 4.5 gm of powdered potassium hydroxide is dissolved in 70 ml of benzyl alcohol, and then 7.2 gm of 8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine are added. The mixture is heated to 150° C. for three hours, cooled, and filtered, the filtrate is mixed with ether, and the precipitate obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)].

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