Реакция #3740

Уравнение реакции

2-amino-2-cyanoacetamide

trimethylorthoformate

n-Propylamine

→

title compound

Выход 61.1%

5-Amino-1-n-propylimidazole-4-carboxamide

Выход 61.1%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураunder reflux for 0.75 hour
3. 3
   Температураto cool
4. 4
   ДругоеThe solid which precipitated
5. 5
   Фильтрацияwas collected by filtration
6. 6
   Другоеcrystallised from methanol

Методика

A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.

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