Реакция #3707

Уравнение реакции

methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate

NaOH

citric acid

→

desired product

Выход 96.7%

4-[2-(2-Chlorophenyl)-2-oxoethyl]benzoic acid

Выход 96.7%

Растворители

CH3OH

water

Условия реакции

Обработка

1. 1
   Температураis refluxed for 3 hours
2. 2
   ДругоеThe reaction mixture is evaporated in vacuo
3. 3
   Другоеto remove the CH3OH
4. 4
   ЭкстракцияThe aqueous phase is extracted with CH2Cl2
5. 5
   ДругоеThe resulting solid is collected
6. 6
   Другоеdried under vacuum

Методика

A mixture of 18.78 g of methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate in 288.8 ml of CH3OH, 72.2 ml of water and 5.2 g of NaOH is refluxed for 3 hours then acidified with 2N citric acid. The reaction mixture is evaporated in vacuo to remove the CH3OH. The aqueous phase is extracted with CH2Cl2 and acidified with 1N HCl. The resulting solid is collected and dried under vacuum to give 17.27 g of the desired product, m.p. 168°-172° C.

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