Реакция #367489

Уравнение реакции

3-(4-methylphenyl)-1,1-dimethylpropanamine

3-trifluoromethylphenyl glyoxal

phenylglyoxal

→

title compound

N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-phenyl ethanamine

Условия реакции

Обработка

1. 1
   ДругоеThe title compound was prepared in the manner
2. 2
   ДругоеThe chromatographed material was recrystallised from hexane

Методика

The title compound was prepared in the manner described in Example 9, replacing 2-(4-methylphenyl)-1,1-dimethylethanamine by 3-(4-methylphenyl)-1,1-dimethylpropanamine and 3-trifluoromethylphenyl glyoxal by phenylglyoxal. The chromatographed material was recrystallised from hexane to give the title compound m.p. 107-110. τ (CDCl3) 8.95 (6H, s), 8.2-8.7 (2H, m), 7.8 (3H, s), 7.3-7.7 (4H, m), 5.7-6.5 (2H, m), 5.5 (1H, t, J=6 Hz), 2.9 (4H, s), 2.7 (4H, m).

Источник